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    Age related dementias

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    SOLTANI_S_2021.pdf
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    Author
    Soltani, Shahab
    Chair
    Duffy, Lawrence K.
    Committee
    Cruz, Bradley K.
    Dunlap, Kriya L.
    Keyword
    Dementia
    Alzheimer's disease
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/11122/12922
    Abstract
    During the last few decades, the average life expectancy has dramatically increased in the U.S.A. and globally. As a result, the diseases associated with age, such as dementia, significantly impact families, society, and government. Dementia is a broad term describing memory loss, cognitive dysfunctions, and limited social skills caused by many factors such as aging, stroke, and genetic background. Although the primary etiology remains unclear but inflammatory reactions, neurodegeneration, vascular abnormalities play an important role in the progression of these disorders. Therefore, treatment is mainly supportive to relieve the symptoms of dementia and not to cure dementia or slow down its progression. This review discusses the most common disorders that cause dementia, including Alzheimer's disease, vascular dementia, and Parkinson's disease, as well as their symptoms, diagnosis, and treatments. Also covered are the studies that were performed on these disorders and animal models for each disease.
    Description
    Thesis (M.S.) University of Alaska Fairbanks, 2021
    Table of Contents
    Chapter one: Introduction -- 1.1. Dementia -- 1.2. Disorders linked to dementia -- 1.2.1. Huntington's disease -- 1.2.2. Parkinson's disease -- 1.3. Progressive dementia -- 1.3.1. Vascular dementia -- 1.3.2. Lewy body dementia -- 1.3.3. Alzheimer's disease. Chapter two: Material and Methods -- 2.1. Diagnostic imaging techniques -- 2.1.1. Magnetic resonance imaging (MRI): -- 2.1.2. MR-spectroscopy -- 2.1.3. Computed tomography (CT) scan -- 2.1.4. Nuclear medicine and positron emission tomography (PET): -- 2.2. Animal model -- 2.2.1. Rodent -- 2.2.2. Primate -- 2.2.3. Canine. Chapter three: Alzheimer's disease, study design, and challenges -- 3.1. Definition -- 3.2. Hypothesis -- 3.3. Specific Aims -- 3.3.1. Specific Aim 1 -- 3.3.2. Specific Aim 2 -- 3.3.3. Specific Aim 3 -- 3.4. Approach -- 3.4.1. Specific Aim 1 -- 3.4.2. Specific Aim 2 -- 3.4.3. Specific Aim 3 -- 3.5. Time Frame and Milestones. Chapter four: Conclusions -- References.
    Date
    2021-12
    Type
    Thesis
    Collections
    Chemistry and Biochemistry

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