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    Resistance to multi organ damage after hemorrhagic shock induced ischemia/reperfusion in arctic ground squirrels

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    Author
    Bogren, Lori
    Olson, JM
    Carpluk, J
    Moore, JT
    Drew, KL
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    URI
    http://hdl.handle.net/11122/1483
    Abstract
    •Worldwide hemorrhagic shock is the number one cause of death in trauma patients, the majority of those die from multi organ dysfunction syndrome [1, 2]. •During hemorrhagic shock (HS), the body undergoes global ischemia as blood pressure drops below the threshold at which tissues can be adequately perfused with blood. •Resistance to ischemic injury is a characteristic of hibernating mammals, including ground squirrels. •There is debate on if this resistance is dependant on hibernation season or if it is an intrinsic plasticity of the organism. QUESTION: Are AGS protected from HS‐induced ischemia reperfusion (I/R) injury on the whole organism and tissue–specific levels and if any protection is dependent upon their hibernation season.
    Date
    2012
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    2012 Research Day Posters

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