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dc.contributor.authorRoss, Jordan
dc.date.accessioned2013-03-28T22:38:12Z
dc.date.available2013-03-28T22:38:12Z
dc.date.issued2012
dc.identifier.urihttp://hdl.handle.net/11122/1565
dc.description.abstractNicotine addiction is a global health problem that affects nearly one-third of the population. Animal models have shown that the beta-4 subunit of nicotinic acetylcholine receptors (nAChR) expressed in the habenulointerpeduncular pathway plays a particularly important role in modulating many of the symptoms of nicotine withdrawal in mice. Ibogaine, a naturally occurring compound extracted from the root bark of a West African shrub, has been shown to reduce drug self administration in animal models of addiction. Ibogaine is considered to be a dirty drug due to its nonspecific interaction at a variety of receptor subtypes. This “nonspecificity” contributes to its hallucinogenic, tremorigenic, and cardiovascular compromising properties. It is thought that the anti-addictive effects of ibogaine are due to its antagonism of the α3β4 nAChR. In this study we explore the interaction of ibogaine on the α3β4 nAChR with the hope of developing more selective, more effective therapeutics in the treatment of addiction.en_US
dc.description.sponsorshipThis research was supported by the IdEA Network of Biomedical Research Excellence INBRE) through an undergraduate student project support (USPS) fellowship.en_US
dc.subjectURSAen_US
dc.subjectResearch Dayen_US
dc.titleCharacterization of ibogaine analogs on the hα3β4 nicotinic acetylcholine receptor.en_US
dc.typePosteren_US
refterms.dateFOA2020-01-25T01:02:22Z


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