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    Characterization of the adenosine A1 receptor in summer and winter Arctic ground squirrels

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    Author
    Carlson, Zachary A.
    Chair
    Drew, Kelly
    Committee
    Rasley, Brian
    Kuhn, Thomas
    Metadata
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    URI
    http://hdl.handle.net/11122/4898
    Abstract
    Hibernation is an adaptation that allows the Arctic ground squirrel (Urocitellus parryii) to survive the harsh arctic winter. Recently the activation of the Adenosine A1 receptor (A₁AR) has been shown to be necessary for entrance into hibernation during the winter but not summer season. In the current study we characterize the A₁AR in the forebrain, hippocampus and hypothalamus of summer and winter AGS. We also tested the hypothesis that increased A₁AR agonist efficacy is responsible for increased sensitization of the A₁AR during the winter season. The resulting ³⁵S-GTPγS binding data indicated an increase in agonist potency during the winter season in all three brain regions. A plausible explanation of our results is that increased potency in the forebrain during the winter season is due to an increase in efficacy as indicated by a greater number of receptors in the high affinity state. In addition ³⁵S-GTPγS binding, [³H] DPCPX saturation and competition assays establish for the first time pharmacological characteristics such as EC⁵⁰, Kd, Kilo and Kihi in AGS brain.
    Date
    2014-12
    Type
    Thesis
    Collections
    Chemistry and Biochemistry

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