• Login
    View Item 
    •   Home
    • University of Alaska Fairbanks
    • UAF Graduate School
    • Chemistry and Biochemistry
    • View Item
    •   Home
    • University of Alaska Fairbanks
    • UAF Graduate School
    • Chemistry and Biochemistry
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Scholarworks@UACommunitiesPublication DateAuthorsTitlesSubjectsTypeThis CollectionPublication DateAuthorsTitlesSubjectsType

    My Account

    Login

    First Time Submitters, Register Here

    Register

    Statistics

    Display statistics

    Inter-individual variation in gene expression in torpid and interbout euthermic Arctic ground squirrels

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Burman_A_2006.pdf
    Size:
    19.60Mb
    Format:
    PDF
    Download
    Author
    Burman, Adlai Max
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/11122/5606
    Abstract
    Alaskan Arctic ground squirrels, Spermophilus paryii, hibernate about seven months per year. During two-week torpor periods, respiration, circulation, metabolism, and catabolism are dramatically decreased, except for brief periods of interbout euthermia. These divergent hibernation states provide a particularly compelling model for variance-based studies of global gene expression. A guiding hypothesis in this Thesis is that Arctic ground squirrels exit interbout euthermia and enter torpor with an invariant metabolic scaffolding of various metabolites that are erected to serve as a ready metabalome for the challenges of the next brief return to euthermia. To develop this hypothesis further, I performed an exploratory data analysis of high-density mouse cDNA micro arrays cross-hybridized with Arctic ground squirrel mRNA to measure transcriptomes in brown adipose, skeletal muscle, and liver tissues. The results revealed that variation in transcript expression profiles were tissue specific and may reflect the degree to which tissues are active during hibernation. These results are encouraging. They justify a more thorough evaluation of the utility of using global variation in transcript expression patterns. In combination with a priori biological knowledge, these patterns will guide future studies into more detailed analyses of hibernation-state dependent and functionally relevant transcripts.
    Description
    Thesis (M.S.) University of Alaska Fairbanks, 2006
    Date
    2006-12
    Type
    Thesis
    Collections
    Chemistry and Biochemistry

    entitlement

     
    ABOUT US|HELP|BROWSE|ADVANCED SEARCH

    The University of Alaska Fairbanks is an affirmative action/equal opportunity employer and educational institution and is a part of the University of Alaska system.

    ©UAF 2013 - 2023 | Questions? ua-scholarworks@alaska.edu | Last modified: September 25, 2019

    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.