• Login
    View Item 
    •   Home
    • University of Alaska Fairbanks
    • UAF Graduate School
    • College of Natural Sciences and Mathematics
    • View Item
    •   Home
    • University of Alaska Fairbanks
    • UAF Graduate School
    • College of Natural Sciences and Mathematics
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Scholarworks@UACommunitiesPublication DateAuthorsTitlesSubjectsTypeThis CollectionPublication DateAuthorsTitlesSubjectsType

    My Account

    Login

    First Time Submitters, Register Here

    Register

    Statistics

    Display statistics

    Addressing feasibility of using microdialysis to monitor adenosine in Arctic ground squirrel (Spermophilus parryii)

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Chi_B_2005.pdf
    Size:
    34.36Mb
    Format:
    PDF
    Download
    Author
    Chi, Bongchu
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/11122/5909
    Abstract
    Both hibernation and anapyrexia are important physiological adaptations. In addition, there is a strong relationship between survival rate and hypothermia during metabolic trauma. Evidence shows that adenosine might be one of the mediators, both of hibernation and anapyrexia. Adenosine is an inhibitory neuromodulator that suppresses neuronal activity when energy stores are low. This inhibitory activity makes adenosine a good candidate for neuroprotection via the suppression of neural activity during metabolic trauma. The main objective of this study was to investigate the feasibility of using microdialysis to monitor extracellular adenosine in the brains of Arctic ground squirrels (AGS), Spermophilus parryii, throughout hibernation. To investigate this feasibility, the basal level of adenosine concentration in AGS was collected using an in vivo microdialysis method. Samples then were analyzed by high performance liquid chromatography (HPLC). Also, the effects of adding an adenosine transporter inhibitor, S-(p-Nitrobenzyl)-6-thioinosine (NBTI), on extracellular adenosine concentration and body temperature (Tb) of AGS were observed. The results of this study indicate that it is not feasible to observe extracellular adenosine concentrations in AGS during hibernation using these techniques.
    Description
    Thesis (M.S.) University of Alaska Fairbanks, 2005
    Date
    2005-12
    Type
    Thesis
    Collections
    College of Natural Sciences and Mathematics
    Theses (Chemistry and Biochemistry)

    entitlement

     
    ABOUT US|HELP|BROWSE|ADVANCED SEARCH

    The University of Alaska Fairbanks is an affirmative action/equal opportunity employer and educational institution and is a part of the University of Alaska system.

    ©UAF 2013 - 2021 | Questions? ua-scholarworks@alaska.edu | Last modified: September 25, 2019

    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.