• Login
    View Item 
    •   Home
    • University of Alaska Fairbanks
    • UAF Graduate School
    • Chemistry and Biochemistry
    • View Item
    •   Home
    • University of Alaska Fairbanks
    • UAF Graduate School
    • Chemistry and Biochemistry
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Scholarworks@UACommunitiesPublication DateAuthorsTitlesSubjectsTypeThis CollectionPublication DateAuthorsTitlesSubjectsType

    My Account

    Login

    First Time Submitters, Register Here

    Register

    Statistics

    Display statistics

    Pilot studies of the genetics of obesity in the western Alaska Native population

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Harrington_K_2004.pdf
    Size:
    61.70Mb
    Format:
    PDF
    Download
    Author
    Harrington, Erik Briggs
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/11122/5927
    Abstract
    Obesity in Alaska Natives is increasing, posing significant health risk for the development of associated diseases. This study examined candidate obesity genes in a set of anonymized Alaska Native DNA samples for loci that might predict obesity risk. DNA samples were divided into three groups according to body mass index: lean (BMI <̲23), in-between (23<BMI <30), and obese (BMI>̲ 30). Screening of 5,043 base pairs from the exons of leptin (LEP), leptin receptor (LEPR), neuropeptide-y (NPY), and melanocortin-4-receptor (MC4R) yielded previously discovered SNPs in NPY and LEPR. Additionally, two known promoter region SNPs in NPY and Uncoupling Protein-2 (UCP2) were analyzed. SNPs were in Hardy Weinberg equilibrium, showed little genetic variation between populations, and were not associated with BMI category. We concluded that the study lacked power to detect an association due to an inability to correct for variables known to affect BMI and a small sample size. However, this study enabled pilot studies of several SNP genotyping platforms and the evaluation of allele frequencies in the Alaska Native population, illuminating the value of known SNP genotyping vs. SNP discovery and the benefit of a direct association study vs. an indirect association study.
    Description
    Thesis (M.S.) University of Alaska Fairbanks, 2004
    Date
    2004-05
    Type
    Thesis
    Collections
    Chemistry and Biochemistry

    entitlement

     
    ABOUT US|HELP|BROWSE|ADVANCED SEARCH

    The University of Alaska Fairbanks is an affirmative action/equal opportunity employer and educational institution and is a part of the University of Alaska system.

    ©UAF 2013 - 2023 | Questions? ua-scholarworks@alaska.edu | Last modified: September 25, 2019

    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.