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dc.contributor.authorSwearingen, Kristian Edward
dc.date.accessioned2015-10-29T01:09:51Z
dc.date.available2015-10-29T01:09:51Z
dc.date.issued2005-12
dc.identifier.urihttp://hdl.handle.net/11122/6112
dc.descriptionThesis (M.S.) University of Alaska Fairbanks, 2005en_US
dc.description.abstractTo elucidate the roles of key neurochemicals in the metabolic suppression of Arctic ground squirrels, a technique is required that is capable of on-line, in vivo, high temporal resolution, quantitative detection of neurotransmitters. A capillary electrophoresis instrument has been built that is coupled to microdialysis by flow-gated injection. Primary amines recovered in vivo via microdialysis are derivatized on-column by cyanide-catalyzed formation of fluorescent isoindoles with naphthalene-2,3-dialdehyde for laser-induced fluorescence detection. The system is capable of detecting base-line glutamate in vivo in 15-second intervals.en_US
dc.language.isoen_USen_US
dc.titleDevelopment and characterization of a capillary electrophoresis instrument with laser-induced fluorescence detection for on-line monitoring of glutamate in vivo via microdialysisen_US
dc.typeThesisen_US
dc.type.degreemsen_US
dc.identifier.departmentDepartment of Chemistry & Biochemistryen_US
refterms.dateFOA2020-03-05T10:56:50Z


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