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dc.contributor.authorBrundage, Cord M.
dc.date.accessioned2017-05-01T23:02:11Z
dc.date.available2017-05-01T23:02:11Z
dc.date.issued2008-08
dc.identifier.urihttp://hdl.handle.net/11122/7418
dc.descriptionThesis (M.S.) University of Alaska Fairbanks, 2008en_US
dc.description.abstractDevelopmental exposure to the neuroteratogen nicotine may affect ventilatory responses to hypercapnia. Developmental changes in normocapnic and hypercapnic neuroventilation of the isolated bullfrog brainstem preparation have been previously characterized. I investigated the effect of 3- and 10-wk chronic nicotine (30 [mu]g/L) exposure on lung burst frequency exhibited by early and late metamorphic bullfrog tadpoles during normocapnia (1.5 % CO₂) and hypercapnia (5.0 % CO₂). Chronic nicotine exposure impairs the hypercapnic neuroventilatory response of early metamorphic tadpoles following both 3- and 10-wk exposure. Late metamorphic tadpoles demonstrated an impaired hypercapnic neuroventilatory response only after 10-wk exposure. Chronic nicotine exposure had no effect on normocapnic neuroventilation. Brainstem preparations from early and late metamorphic tadpoles and juvenile bullfrogs were exposed acutely to 18 [mu]g/L nicotine. Acute nicotine had no effect on normocapnic or hypercapnic neuroventilation of early metamorphic tadpoles. Late metamorphic tadpoles and juvenile bullfrogs demonstrated depressed normocapnic neuroventilation in response to acute nicotine exposure, while late metamorphic tadpole brainstems responded significantly to hypercapnia during acute exposure. This suggests that bullfrogs have a differential response to acute nicotine exposure that increases with development. Collectively these data suggest that the consequences of developmental nicotine exposure differ between acute and chronic exposure and throughout bullfrog development.en_US
dc.description.tableofcontents1. Timing and duration of developmental nicotine exposure contribute to attenuation of the tadpole hypercapnic response -- 2. Nicotine affects the normocapnic and hypercapnic neuroventilation of bullfrogs in a developmental stage dependent manner -- General conclusions -- Literature cited.en_US
dc.language.isoen_USen_US
dc.titleNicotine exposure in the developing bullfrog: influences on neuroventilatory responses to CO₂en_US
dc.typeThesisen_US
dc.type.degreemsen_US
dc.identifier.departmentDepartment of Biology and Wildlifeen_US
refterms.dateFOA2020-01-25T02:10:17Z


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