• Characterization of ibogaine analogs on the hα3β4 nicotinic acetylcholine receptor.

      Ross, Jordan (2012)
      Nicotine addiction is a global health problem that affects nearly one-third of the population. Animal models have shown that the beta-4 subunit of nicotinic acetylcholine receptors (nAChR) expressed in the habenulointerpeduncular pathway plays a particularly important role in modulating many of the symptoms of nicotine withdrawal in mice. Ibogaine, a naturally occurring compound extracted from the root bark of a West African shrub, has been shown to reduce drug self administration in animal models of addiction. Ibogaine is considered to be a dirty drug due to its nonspecific interaction at a variety of receptor subtypes. This “nonspecificity” contributes to its hallucinogenic, tremorigenic, and cardiovascular compromising properties. It is thought that the anti-addictive effects of ibogaine are due to its antagonism of the α3β4 nAChR. In this study we explore the interaction of ibogaine on the α3β4 nAChR with the hope of developing more selective, more effective therapeutics in the treatment of addiction.