It is important to assess from a holistic perspective the sustainability of road salt widely used in winter road maintenance (WRM) operations. The importance becomes increasingly apparent in light of competing priorities faced by roadway agencies, the need for collaborative decision-making, and growing concerns over the risks that road salt poses for motor vehicles, transportation infrastructure, and the natural environment. This project introduces the concept of Life Cycle Sustainability Assessment (LCSA), which combines Life Cycle Costing, Environmental Life Cycle Assessment, and Social Life Cycle Assessment. The combination captures the features of three pillars in sustainability: economic development, environmental preservation, and social progress. With this framework, it is possible to enable more informed and balanced decisions by considering the entire life cycle of road salt and accounting for the indirect impacts of applying road salt for snow and ice control. This project proposes a LCSA framework of road salt, which examines the three branches of LCSA, their relationships in the integrated framework, and the complexities and caveats in the LCSA. While this framework is a first step in the right direction, we envision that it will be improved and enriched by continued research and may serve as a template for the LCSA of other WRM products, technologies, and practices.